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They do not differ in the fundamental constraint: molecules above roughly 500 daltons don't cross intact stratum corneum passively, and the botanicals that do fit under that threshold arrive at doses two to three orders of magnitude below anything studied

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DXA data from the STEP-1 and SURMOUNT-1 trials show meaningful lean mass reduction during GLP-1-driven weight loss: approximately 9.7% of total lean tissue with semaglutide in STEP-1, and 10.9% with tirzepatide in SURMOUNT-1

These effects are often transient and may diminish with continued exposure

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While Retatrutides 12 mg might seem larger than semaglutides 2.4 mg, it reflects a unique pharmacologic profile rather than sheer potency