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Furthermore, in terms of absolute effects, the cardiovascular benefits of GLP-1 RA and SGLT2i were less pronounced in people with three or more cardiovascular risk factors than in those with established CVD

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After completion of the single-dose cohorts, an expansion panel randomized postmenopausal females at a ratio of 1:1:1:1 to receive IV doses of anti-ActA 10 mg/kg alone, anti-GDF8 6 mg/kg alone, co-administration of anti-GDF8 6 mg/kg + anti-ActA 10 mg/kg, or placebo

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