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Importantly, in vitamin B-12 deficiency, high folate was associated with 16% lower total vitamin B-12 concentration than the state of vitamin B-12 deficiency with nonelevated folate status

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The documented mechanisms are: VEGF stimulation in dermal fibroblasts that supports the microvascular network feeding the follicle, collagen and glycosaminoglycan synthesis at the follicular basement membrane, anti-inflammatory signaling that calms the chronic micro-inflammation associated with androgenetic alopecia, and direct follicular signaling that extends the anagen growth phase

doi:10.1155/2012/324832 Ma WH, Li M, Ma HF, et al

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Interestingly enough, the KPV peptide alone exerts an even more potent anti-inflammatory effect than the whole -MSH peptide