NICE recommends GLP-1 therapies for adults with BMI 35 kg/m or BMI 3034.9 kg/m with weight-related comorbidities, limited to 2 years' treatment
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For example, while the absence of functional GHR was reported to cause an increase in systemic GH levels, a decrease in circulating IGF-1 level (but still present), and a delay in puberty onset with a reduced number of ovarian follicles, these animals could still reproduce, but with a smaller litter size (2124)
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doi: 10.1074/jbc.M114.595363 52 WaltA.KahnM
Improved experimental accuracy: Maintains consistent research results by holding concentration steady over time