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To enhance the quality of evidence, larger sample sizes and multi-center, double-blind RCTs should be conducted

However, under certain pathological conditions, such as cancer or neurological disorders, the levels of free redox metals can increase

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These changes in gene expression indicate enhanced cell division following the initial sulfur treatment response

Alternative biomarkers might also include imaging, physiology and clinical data that reflect an underlying pathophysiological process that could be responsive to therapy