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Effects of oridonin on hepatic cytochrome p450 expression and activities in pxr-humanized mice

CDKN1A was upregulated 1.5-fold following PQ challenge and was progressively upregulated further with both NAC (1.7-fold) and L-NAC (1.9-fold) pretreatment

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Therefore, salivary HO-1 concentrations might offer useful evidence to enable the distinguishing between patients with early-stage PD and healthy controls