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Activated IGF-1R transduced the signal 49,50 to AKT as increased levels of pAKT were observed in GNE knockdown and mutant cells (Fig

h , Bar graph summarizing the effect of NMDA-induced inward current after control (aCSF, n = 5 neurons), GLP-1 (50 M, n = 5 neurons), MK-801 (50 M, n = 5 neurons) or GLP-1MK-801 (50 M, n = 5 neurons)

Therefore, future experimental models and human studies should explore in depth the specific mechanism of action of acupuncture on pathological changes in Tau and how this traditional medical technique can be effectively utilized to treat or prevent TBI-induced neurodegenerative diseases (Liu, 2023)