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doi:10.1371/journal.pone.0003815

Dark patches are caused by several reasons: Sun exposure increased UV light causes an increase in melanin, and resulting hyperpigmentation Hormonal influences commonly causes melasma and skin hyperpigmentation in women Chemicals chemical irritants can cause pigmentation and discoloration on the skin Acne breakouts after an acne flare, the skin may become discolored, called post-inflammatory hyperpigmentation (PIH), which appears almost as acne scars

Inflammation, repair signaling, angiogenesis, immune modulation, and remodeling occur at the same time

Recently, in high-grade glioblastoma, Cirillo et al

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