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Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice

Novo Nordisks major semaglutide-related patents here will not start to expire until late 2031, meaning generics probably wont enter the market until 2032 at the earliest

Adiels M, Taskinen MR, Packard C, Caslake MJ, Soro-Paavonen A, Westerbacka J, Vehkavaara S, Hakkinen A, Olofsson SO, Yki-Jarvinen H, Boren J (2006) Overproduction of large VLDL particles is driven by increased liver fat content in man

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Semaglutide, originally developed to help manage Type 2 diabetes, has been shown to achieve remarkable weight-loss results in clinical studies