It was never going to be an anti-obesity drug. In mouse studies, AOD-9604 was shown to break down fat and prevent weight gain, but it was also shown that this effect over the longer term was dependent on a specific receptor When you give AOD-9604 to mice that are deficient in this receptor the weight-losing effect is lost. Its not surprising that AOD-9604 doesnt work in humans because the receptor on which it appears to be dependent is not the same in mice and humans. For anybody who knows anything about peptides used for fat-burning, the problem should have been obvious from the get-go
L., et al., FirstinHuman Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction, Journal of Clinical Oncology 34, no
Excess B12 is excreted through urine as a water-soluble vitamin, reducing the risk of toxicity
Instead, it often presents as a collection of seemingly unrelated problems that can easily be mistaken for something else
The packaging is intended to minimize exposure to moisture, temperature fluctuations, and physical damage that can degrade peptide materials before they reach the lab
Cosar E, Mamillapalli R, Ersoy GS, Cho S, Seifer B, Taylor HS