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Aroda VR, Erhan U, Jelnes P (2023) Safety and tolerability of semaglutide across the SUSTAIN and PIONEER phase IIIa clinical trial programmes

MD simulation The cell membrane in the simulation system was composed of dioleoylphosphatidylethanolamine (DOPE)dioleoylphosphatidylglycerol (DOPG) lipids with a 3:1 ratio (90 and 30 molecules, respectively)

Why It Matters The drugs, known as GLP-1 receptor agonists, were initially developed to treat Type 2 diabetes but have become a cultural phenomenon for their ability to suppress appetite and help patients lose as much as 20 percent of their body weight in clinical trials

Pooled semaglutide data showed a significant reduction of 32% in risk of stroke compared with placebo