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Gastrointestinal side effects remain one of the most significant challenges associated with many currently marketed GLP-1 therapies and are a major factor affecting long-term patient adherence

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GLP-1: A breakthrough for diabetes and obesity Scientists in the 1980s made a discovery that would one day lead to drugs now used around the world to treat diabetes and help people lose weight

Using biotin-probe profiling, gene knockout/knock-in models, UPLC-MS metabolomics and computational simulations, the researchers demonstrated that: CD36 binds multiple PROTAC molecules (including SIM1-Me, MZ1 and ARV-110) as well as large-molecule drugs such as rapamycin, navitoclax, birinapant, tubacin and doxorubicin, thereby promoting their cellular uptake and pharmacological activity

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