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After a 6-week lead-in period, patients who received single-blind sibutramine had on average a 2.2 kg reduction of body weight, a 2.0 cm reduction of waist circumference, a 3.0 mm Hg decrease in systolic blood pressure, a 1.0 mm Hg decrease in diastolic blood pressure, and a 1.5 mm Hg decrease in pulse rate

Qualitatively, both self-report and EHR data showed similar distributions for weight loss efficacy (Extended Data Fig

Staying hydrated, avoiding frequent snacking, and giving your body enough time to adjust to each dose also play an important role

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