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Studies show that patients losing 5-10% body weight may require 10-25% reductions in levothyroxine dosing to maintain optimal TSH levels

References Allocati N, Masulli M, Di llio C, Federici L (2018) Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

Already, Wegovy has been approved to reduce the risk of heart problems

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Lancet Diabetes Endocrinol (2018) 6:27586

The GCL enzyme is a heterodimer formed by two subunits: the heavy subunit or glutamate cysteine ligase catalytic subunit (GCLC, 73 kDa) and the light subunit or glutamate cysteine ligase modulating subunit (GCLM, 30 kDa)