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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

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AOD9604 is not FDAapproved for any medical indication, and FDA advisory documents note concerns about immunogenicity, peptide-related impurities, and lack of sufficient safety and efficacy data