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While polygenic risk scores (PRS) address part of this architecture by aggregating validated risk alleles from GWAS, the proposed workflow further considers the potential cumulative burden of variants typically deemed benign, aiming to bridge the gap between population-level risk estimation and individualized interpretation (Torkamani et al., 2018)

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However, the CSC pool itself is not homogeneous

Putting risk in perspective The idea that a supplement can change body odor is unsettling but it is a real and explainable phenomenon for a subset of people