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For the human study, data are expressed as the mean SEM

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Biogenic amines including tyramine, putrescine, and cadaverine compete for the same DAO enzymatic clearance as histamine meaning total amine load is a more meaningful metric than histamine alone

Differentiation comes from choosing collagen peptides with a specific bioactive design, a defined mechanism of action, and published clinical substantiation

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Although the molecular mechanisms linking circadian rhythms to inflammatory mediators are not fully understood, circadian disruption is known to disturb cytokine regulation