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In contrast, T2DM exhibits more pronounced endothelial dysfunction driven by hypertension and dyslipidemia, which synergize with hyperglycemia to increase vascular permeability (82, 83)

However, severe vomiting, abdominal pain, dehydration, persistent constipation, or vision changes need medical attention

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The anti-diabetic efficacy of diverse polyphenols has been demonstrated in both in vivo and in vitro studies, supporting their potential as therapeutic agents (388, 389)

IBS patients need to avoid long periods of not eating (to prevent bile acid buildup or hunger-triggered motility which can cause pain), so managing GLP-1 nausea is important

S-Adenosyl methionine is involved in various biochemical processes, but its use requires caution