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The BNF updated their website but the information about frequency remains the same Hydroxocobalamin

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to provide its chemo-protective effects, it is likely that doses much higher than the recommended physiological doses of melatonin (for example, 1 mg/kg) would be necessary [219]

Jin ZL, Liu W

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The samples were centrifuged (5 min, 3,000 g) before the transfer of an aliquot of the upper aqueous layer to an autosampler vial while applying filtration by a filter with a pore size of 0.2 m