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Furthemore, an increased serotonin metabolism was demonstrated by diminished hypothalamic serotonin levels, lowered 5-hydroxytryptamine (5-HT)/tryptophan ratios and elevated 5-hydroxyindoleacetic acid/5-HT ratios, indicating dysregulated serotonergic system (Jia et al., 2024)

Some side effects are common, especially nausea, constipation, diarrhoea, reduced appetite, and fatigue

history of blood diseases

Journals of Gerontology Series A

Clinical trials have not established a direct causal link between semaglutide and muscle pain, though some patients report musculoskeletal discomfort

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