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Enrichment analyses, including Gene ontology, Local network cluster (STRING), reactome pathways, protein domains, and features (Pfam and InterPro) were performed based on gene lists from the PPI network

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This extended signaling allows for a steady, basal increase in growth hormone and IGF-1 levels without causing the aggressive spikes that disrupt natural endocrine rhythms

In the long-term toxicity experiment, continuous injection of AOD 9604 (10 mg/kg) for 8 weeks did not cause abnormal liver and kidney functions or fluctuations in blood glucose, providing a safety basis for its further research and application

PubMed Central , Frontiers in Cell and Developmental Biology , vol

Pharmacodynamic Considerations: Overlapping Biology, Not Opposing Effects Where the interaction picture becomes more nuanced is at the pharmacodynamic level