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And gallbladder issues are a known risk with rapid weight loss from any cause, not just GLP-1 medications

doi: 10.1186/s12970-017-0177-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 68

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to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes and established cardiovascular disease

GLP-1 peptide drug therapeutics have revolutionized the treatment of type 2 diabetes and obesity due to their ability to regulate blood glucose levels by promoting insulin secretion, inhibiting glucagon release, and delaying gastric emptying