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Those Prepared for Dietary and Exercise Adjustments: Complement efforts like a balanced diet and increased physical activity

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(Of note, this study excluded individuals with diabetes from the study population)

Because the glucagon receptor is highly expressed in the liver, adding GCGR agonism gives the molecule a tissue-specific mechanism for reducing hepatic fat and, hypothetically, addressing the inflammation and fibrosis that define MASH

The authors offer this explain their findings this way: Here we demonstrate that tirzepatide, a dual GLP-1R/GIPR agonist, affects alcohol intake and alcohol-related responses across both sexes in rodents