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doi: 10.1111/add.15204

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Under this condition, HIF-1 becomes stabilized and subsequently translocates to the nucleus, where it binds to hypoxia-responsive elements within target genes, thereby promoting metabolic programming, notably the upregulation of anaerobic glycolysis (37,38)

IM injections are the standard for rapidly restoring B12 levels, particularly in severe cases and patients with absorption issues