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L.KorkinaO.TengX.et al (2008)

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Yes, metformin has been associated with modest weight loss

Sculean A, Chiantella GC, Windisch P, Donos N

A predicted site in selenoprotein P (SELENOP, Figure 2C) is at position 56, 3 residues prior to the first selenocysteine, such that cleavage here would likely interfere with the N-terminal redox activity, possibly without affecting the Se-transport function of the rest of the protein

Prevalence of pruritus in patients with chronic liver disease: a multicenter study