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Recent studies have pointed out that GLP-1 can increase the expression of ABCA1 and ABCG1 in ApoE -/- mice, thereby reducing the area of aortic plaque in HF raised ApoE -/- mice and realizing the reverse transport of aortic plaque

There is limited evidence that supplements like berberine, fiber, and probiotics may help raise GLP-1 in the body

Pre-clinical studies showed that anti-atherogenic effect of GLP-1 is independent of modulation of plasma lipid levels and depends on anti-inflammatory response

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however, it also resulted in an undesired elevation in the controlled attenuation parameter (evaluating LFC)