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[92] The mechanism underlying melatonin-induced headaches remains unclear, though vascular effects or changes in neurotransmitter activity may contribute

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Han et al., 2021

In addition, JHU-083 reduces the expression of IDO (an enzyme that mediates tryptophan metabolism) by inhibiting the phosphorylation of STAT1 and STAT3 in tumor cells, MDSCs, and TAMs, thereby decreasing the kynurenine/tryptophan ratio and enhancing the functions of antitumor T cells 150

GLP-1 medications slow gastric emptying and reduce appetite, which can either improve or worsen these symptoms depending on individual gut composition

Oral GLP-1s may also provide more nuanced treatment regimens, such as combining the rapid weight loss of injectables maintaining a desired body weight with orals