Binding of apoptosis-linked gene-2-interacting protein X to its N-terminal region promotes secretion, whereas keratin 20 binding at this region inhibits secretion and thereby prevents ferroptosis in kidney tubular cells [152]
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The anti-diabetic drugs glitazones which improves mitochondrial functions (such as activities of cI and cIV) and biogenesis (Ghosh et al., 2007) did lower the incidence of PD in retrospective cohort studies (NINDS Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators, 2015)