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8.6 Renal Impairment BYETTA is not recommended for use in patients with end-stage renal disease or severe renal impairment (creatinine clearance 7.0% entered a 30-week intervention phase and were randomized to add either BYETTA or insulin lispro to their existing regimen of insulin glargine and metformin
may be repeated or increased as required Acute Pulmonary Edema * Usually 2040 mg IV initially Adverse Effects Electrolyte Disturbances * Hypokalemia * Hyponatremia * Hypomagnesemia * Hypocalcemia Other * Dehydration * Hypotension * Dizziness * Hyperuricemia (may precipitate gout) * Ototoxicity (especially with high IV doses) Contraindications * Severe dehydration * Anuria * Severe electrolyte depletion * Hypersensitivity to furosemide Monitoring * Fluid balance * Blood pressure * Renal function * Serum electrolytes (especially potassium) * Daily weight in patients with edema Drug Interactions * Digoxin (risk increased with hypokalemia) * Aminoglycosides (increased ototoxicity) * NSAIDs (may reduce diuretic effect) * Lithium (increased lithium toxicity) * Furosemide is a loop diuretic acting on the thick ascending limb of the loop of Henle
Weight loss via GLP-1s like Ozempic ($17.45B in 2024 sales, up 25% YoY) proved even more lucrative than erectile dysfunction, with Ro's GLP-1 sales 3x'ing between January 2023 and August 2024, pushing topline growth to 66% in 2024 (vs 14% in 2023 and 5% in 2022) and lifting average transaction value from ~$93 to ~$134, while Hims & Hers hit 100K GLP-1 members and ~$343M in annualized GLP-1 revenue by the end of 2024
Shortly after its production, tirzepatide became wildly popular because of the amazing weight loss results it produced
They are used primarily for weight management and the treatment of type 2 diabetes
