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It provides essential protection from free radicals, highly unstable, reactive molecules (also known as reactive oxygen species' (ROS)), which are capable of damaging organic substances such as lipids, proteins and DNA

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4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)