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Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]

It gave the field the confirmation that we were on the right track, said Holst

The mechanism appears to involve interaction with the endogenous opioid systemDSIP modulates enkephalin and beta-endorphin release, suggesting opioid-system cross-talk

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