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Antioxidant Gene Expression and Oxidative Stress Pathways The AEDG sequence has also been investigated for its effects on oxidative stress response pathways a research domain that intersects with its pineal and telomere-related activities, since oxidative damage is both a driver of telomere attrition and a consequence of melatonin decline

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Improved understanding of the contributors to the observed decrease in dementia incidence, quantifying the role of changes in cardiovascular risk profiles and educational attainment for example, may open opportunities to accelerate prevention efforts and to better use public health investments not specifically targeted to AD/ADRD (e.g., initiatives aimed at improving cardiovascular health)

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