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GLP-1 Agonist is FDA-approved for chronic weight management, indicating a review of its safety profile for longer-term use in appropriate candidates

Compared with the previous systematic review, although more trials and sample sizes were included in our study, it is still relatively small

The complex interaction relationship between iron metabolism disorders and changes in the abundance of gut microbiota (especially Bifidobacterium ) revealed in this section provides evidence for clarifying the molecular mechanism of the hypothetical pathological axis of iron overload-disruption of gut homeostasis-ferroptosis in OA, and suggests that targeted regulation of the iron-microbiota interaction may become a potential new strategy for the prevention and treatment of OA