retatrutide mechanism triple agonist glp-1 gip glucagon receptor Dual and Gut Peptide Agonists on the Horizon for the Treatment of Type 2 Diabetes and Obesity. An Overview of Preclinical and Clinical Data Science Behind GLP 1 GIP

Biomedicine and Pharmacotherapy , 120

A single overnight at room temperature typically causes 2 to 5 percent potency loss for reconstituted retatrutide

Although conventional hypoglycemic agents effectively control blood glucose levels, they inadequately prevent major adverse cardiovascular events, such as myocardial infarction and stroke

Compound identity at a glance Name: Retatrutide INN: LY3437943 Class: Triple incretin receptor agonist Structure: 39-amino-acid synthetic peptide Dosing interval: Once weekly (research protocols) Developer: Eli Lilly For the full molecular reference (molecular formula, molecular weight, CAS number and the 39-amino-acid sequence) see the Retatrutide molecular profile

Updated March 15, 2026

J Hypertens 2015;33:172941