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GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent mannermeaning they only promote insulin release when blood glucose levels are elevated, which significantly reduces the risk of hypoglycaemia compared with some other diabetes medicines

Proc Natl Acad Sci 79(2):345349 Ma Y, Huang Y, Yan L, Gao M, Liu D (2013) Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance

Medications like Mounjaro and Wegovy are GLP-1 receptor agonists , meaning they're clinically proven to mimic this hormone directly, GLP-1 patches, on the other hand, are not

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R