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In some embodiments, the osmolarity at a target site of action (e.g., the perilymph) is about the same as the delivered osmolarity (i.e., osmolarity of materials that cross or penetrate the round window membrane) of any formulation described herein

Astrocytic demise is manifested in classical clasmatodendrosis with cell swelling and fragmentation of processes

Regular evaluations can guarantee safety and effectiveness, allowing for essential dosage adjustments

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