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Enhances NO synthesis to improve local vasodilation and oxygenation

Many patients can feel an improvement after just one injection

The 2.0mL option at 10mg/mL still works for the 4-8mg range but becomes impractical for 12mg doses since you would need to draw 120 units, which exceeds the capacity of a standard 100-unit insulin syringe

may also be positive in patients with SLAP lesions

NICE guidance emphasises the importance of investigating the underlying cause of B12 deficiency rather than simply treating with supplements, as this may identify serious conditions requiring specific management

The manufacturer submitted literature to demonstrate that the Game Ready System has the ability to replace, reduce, or avoid intraoperative or postoperative opioid use or the quantity of opioids prescribed in a clinical trial or through data published in a peer reviewed journal