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The existence of several amino acid analogues that can compete with ASCT2 substrates for binding sites and reduce amino acid translocation has been reported(Table 4) [168]
Furthermore, as a member of the TMPRSS family of serine proteases, hepsin plays crucial roles in various biological processes, including maintaining liver architecture, regulating cell growth, and influencing other serine proteases and lipid metabolism (Hsu et al
It preferentially activates the growth hormone releasing aspects of these receptors while having less effect on the appetite stimulating pathways
The primer sequences for the targeted genes (housekeeping gene 28S rRNA and the inflammatory cytokines TNF-, IL-1, and IL-6) are presented in Supplementary Table S1
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