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Phase 1 clinical study Clinical study design This was an FIH, double-blind, randomized, placebo-controlled study consisting of two parts: SAD and MAD in participants with obesity (NCT04478708)

DOI: 10.15406/ijmboa.2025.08.00198 Pediatric obesity is an escalating public health concern with long-lasting metabolic, inflammatory, and psychosocial consequences (Graphical abstract)

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The 5-year cumulative incidence estimates for opioid-involved overdose or opioid overdose-related death ranged from approximately 1.5% to 4% across study sites, counting only the first event during follow-up

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