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Sodium-glucose co-transporter 2 inhibitors (SGLT2is) have emerged as a breakthrough therapy for the treatment of diabetes mellitus (DM) reducing key cardiovascular and kidney endpoints

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In rodent models, a number of studies have found that GLP-/GIP dual agonists group mice have reduced fat mass, decreased circulating cholesterol, and lost weight, which has excellent weight loss effect

doi: 10.1016/j.expneurol.2021.113708 143

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