This research was funded by the Spanish Ministry of Science and Innovation, Interministerial Commission for Science and Technology (CICYT - project RTI2018-095658-B-C33) and Centre for the Development of Industrial Technology (CDTI CIEN program, projects GLOBALVITI and CAVAWINNER).
For context, the same patients on metformin (the most common first-line diabetes drug) lose about 2 to 3 pounds
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Pro-inflammatory cytokines like IL-1, IL-6, and TNF activate macrophages, neutrophils, and endothelial cells through NADPH oxidase, resulting in a greater production of superoxide and H2O2 (Takada et al., 2003