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Along with ceramides 4 and 7, they also play a vital role in epidermal integrity and serve as the main storage areas for linoleic acid (a fatty acid that's also very important for barrier repair)

The absence of these peptides makes it less affinity to IGFBPs, thus more effective because it will stay in the host body long enough to exert the desired pharmacological actions

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Higher doses in rats associated with maternal toxicity increased the incidence of rib malformations in offspring at 1000 mg/kg, or approximately 100-times the clinical dose, based on AUC

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