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Spence JD, Yi Q, Hankey GJ

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Mechanism of Action AOD9604 exerts its metabolic effects through mechanisms that remain incompletely characterized but appear to involve direct stimulation of lipolysis and inhibition of lipogenesis in adipose tissue through pathways independent of the classical growth hormone receptor

This alcohol-induced steatosis is further compounded by the systemic insulin resistance from obesity, which independently drives an influx of FFA to the liver

Sakai D, Nakai T, Mochida J, Alini M, Grad S: Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus