split dosing semaglutide 2x a week injections?? : r/Semaglutide Should You Split Your GLP-1

Discussion With the popularity of GLP-1 RA medications and challenges in access and insurance coverage, we will continue to monitor these prescribing and dispensing trends over time

Further studies are warranted in order to delineate the importance of circulating (endocrine) versus tissue (autocrine/paracrine) levels of IGF-1 in disease risk and progression

The American Society of Anesthesiologists (ASA) initially suggested patients taking GLP-1 medications should stop before elective surgery

10.1152/physrev.00043.2006 Physiol

When retatrutide continuously activates GLP-1 receptors on sensory neurons, those neurons can become "trained" to fire more easily, lowering the threshold for what triggers a sensory response

So a separate set of companies decided not to launch generics at all