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[121], in the vincristine-induced CIPN model, curcumin at doses of 30 and 60 mg/kg significantly increased the nociceptive threshold and levels of endogenous antioxidant enzymes, decreased vincristine-induced calcium accumulation, nitric oxide (NO), and lipid peroxidation (LPO) levels in the sciatic nerve of mice, and exerted analgesic, calcium inhibitory, neuroprotective, and antioxidant effects in a dose-dependent manner, which in turn ameliorated vincristine-induced neuropathy in mice

BPC-157 evidence base is concentrated in a single research group (Sikiric and collaborators at the University of Zagreb), with limited fully independent replication

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Possibly, but weight-loss plans deserve extra care because nutrient adequacy can shift when calories are restricted

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