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Mediators like PGE 2 can stimulate local estrogen production within lesions by activating enzymes like aromatase, further driving the estrogen-dependent nature of the disease [71]

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Patients with systemic or local inflammatory conditions were excluded by 88% of trials

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J Pineal Res 61(2):20817 Chen L, Liu L, Li Y, Gao J (2018) Melatonin increases human cervical cancer HeLa cells apoptosis induced by cisplatin via inhibition of JNK/Parkin/mitophagy axis