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Ethics declarations Competing interests J.L

Freeze-thaw rule If long-term storage is needed, freeze single-use aliquots rather than the same vial over and over

The most common adverse effects of retatrutide were gastrointestinal (GI) such as nausea, diarrhea, vomiting and constipation reported by 13-50% in the retatrutide groups compared with 35% in the dulaglutide group, and 13% in the placebo group

The SELECT trial reported a 20% reduction in major adverse cardiovascular events with semaglutide versus placebo in patients with overweight/obesity and established cardiovascular disease, without diabetes [34] [35]

doi: 10.1007/s11695-014-1560-z 11 TsesmeliNCoumarosD

For semaglutide specifically, the semaglutide reconstitution process and tirzepatide reconstitution process each have specific water-to-peptide ratios that affect both dosing accuracy and solution stability