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After adding either the cGASSTING pathway inhibitor C-176 or GLP-1RAs, the cGAS-STING signaling pathway was inhibited effectively accompanied with suppression of chondrocyte ferroptosis, inflammatory factor expression, and osteophyte formation on articular surfaces, and enhancement of cartilage repair, reinforcing a causal link between cGASSTING activation and chondrocyte ferroptosis in RA

[DOI] [PMC free article] [PubMed] [Google Scholar] 16

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[16] on tirzepatide and Nagendra et al