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Similarly, in an earlier study, the up-regulation of iNOS in the intestinal epithelial cells (IECs) has been closely associated with the initiation and maintenance of intestinal inflammation in IBD, which can be potentially used as a non-invasive blood-based biomarker of IBD, as documented (139)

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10.1016/j.cell.2017.10.035 [DOI] [PMC free article] [PubMed] [Google Scholar] Shigeto, M