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The MHRA uses Yellow Card data to identify emerging safety signals, update prescribing guidance, and, where necessary, take regulatory action

Comparative Efficacy Profile Matrix: Parameter Target

A 2023 analysis in Nature Metabolism confirmed that glucagon receptor agonism drives thermogenesis and fat mobilisation independent of food intake changes

It belongs to a novel class of agents known as triple receptor agonists , distinguishing it from earlier-generation treatments such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 receptor agonist)

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